{"id":14,"date":"2021-02-18T10:15:22","date_gmt":"2021-02-18T10:15:22","guid":{"rendered":"http:\/\/beta.biospacelab.com\/?page_id=14"},"modified":"2026-10-02T12:53:59","modified_gmt":"2026-10-02T10:53:59","slug":"applications","status":"publish","type":"page","link":"https:\/\/biospacelab.com\/zh\/applications\/","title":{"rendered":"\u7533\u8bf7"},"content":{"rendered":"\t\t
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PRECLINICAL IMAGING APPLICATIONS<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Explore biology across a wide range of preclinical applications<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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From oncology and neuroscience to virology, stem cell research and biodistribution, explore how Biospace Lab imaging technologies help researchers visualize, quantify and follow biological processes in vivo and ex vivo.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ONCOLOGY<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Tumor growth \u00b7 Metastasis \u00b7 Therapy response<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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NEUROSCIENCE<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Brain imaging \u00b7 Neural activity \u00b7 Awake imaging<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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stem cell biology<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Cell tracking \u00b7 Migration \u00b7 Differentiation<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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VIROLOGY<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Viral infection \u00b7 Disease progression \u00b7 Treatment response<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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PHARMACOLOGY<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Drug distribution \u00b7 Radiotracers \u00b7 Quantification<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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OTHER APPLICATIONS<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Cerenkov<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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ONCOLOGY<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Biospace Lab contributes to the great efforts devoted to cancer research, which represents a major concern for human health.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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detect primary tumor and metastases simultaneously<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Discriminate primary tumor and metastases thanks to the high dynamic<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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TRACK TUMOR PROGRESSION
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Follow disease evolution longitudinally.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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EVALUATE THERAPY RESPONSE
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Quantify biological response over time.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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COMBINE ANATOMY & FUNCTION<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Localize optical signals within their anatomical context.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Bar, I. et al<\/em>. Silencing of casein kinase 1 delta reduces migration and metastasis of
triple negative breast cancer cells<\/b>. Oncotarget (2018)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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<\/strong><\/p>

Non-targeted (control)<\/strong>
The primary tumor grows over time in triple negative breast cancer xenografts<\/p>\n


<\/strong><\/p>

Silencing of CSNK1D<\/strong>
CSNK1D knock-down slows down tumor development<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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CSNK1D knock-down prevents metastasis formation, while lung metastases develop in shNT triple negative breast cancer xenografts<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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The camera’ wide dynamic range makes it possible to monitor the primary tumour as well as to detect lung metastases.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Bar, I. et al. Silencing of casein kinase 1 delta reduces migration and metastasis of
triple negative breast cancer cells<\/b>. Oncotarget (2018)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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1st<\/sup> line: Non-targeted (control)
<\/strong>The primary tumor grows over time in triple negative breast cancer xenografts<\/p>

2nd<\/sup> line Silencing of CSNK1D<\/strong>
CSNK1D knock-down slows down tumor development<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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CSNK1D knock-down prevents metastasis formation, while lung metastases develop in shNT triple negative breast cancer xenografts<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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The highly dynamic range of the camera allows to follow-up the primary tumor as well as to detect lung metastases.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Jarry, U. et al.<\/em> Orthotopic model of lung cancer: isolation of bone micro-metastases
after tumor escape from Osimertinib treatment<\/strong>. BMC Cancer<\/em> (2021)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Orthotopic model of lung cancer:<\/strong>
– lung primary tumor nesting
– metastases dissemination after Osimertinib treatment<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Bone micro-metastases<\/b> were easily detected using bioluminescence, allowing isolation of tumor cells otherwise undetectable by macroscopic observation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Germanova, D. et al.<\/em> Myeloid tumor necrosis factor and heme oxygenase\u20101 regulate the progression of colorectal liver metastases during hepatic ischemia\u2010reperfusion<\/strong>. International Journal of Cancer<\/em> (2021)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Bioluminescence imaging. CCD camera image capture of C57BL\/6 mice inoculated 14 days before with luciferase-MC-38 cells (T group) and undergoing liver IR 12 days before (T + IR group)<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Serial liver emitted photon quantification at 9 and 14 days postluciferase-MC-38 inoculation in C57BL\/6 mice (*P < .05, and ***P < .001 two-tailed nonparametric Mann-Whitney test). IR, ischemia-reperfusion<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Bogeas, A. et al.<\/em> Changes in chromatin state reveal ARNT2 at a node of a tumorigenic transcription factor signature driving glioblastoma cell aggressiveness<\/strong>. Acta Neuropathologica<\/em> (2018)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\u00a0<\/strong>shCTL (control)
<\/strong>Mice with
orthotopic xenograft of glioblastoma
stem-like cells (left) almost inevitably develop a tumor\u00a0<\/strong><\/p>

Silencing of ARNT2<\/strong>
ARNT2 knock-down (right) strikingly reduces tumor incidence in mice grafted with glioblastoma
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Longitudinal analysis of bioluminescence allows to reveal tumor incidence and the timing of its occurrence.<\/p>

\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Bogeas, A. et al.<\/em> Changes in chromatin state reveal ARNT2 at a node of a tumorigenic transcription factor signature driving glioblastoma cell aggressiveness<\/strong>. Acta Neuropathologica<\/em> (2018)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\u00a0<\/strong>shCTL (control)
<\/strong>Mice with orthotopic xenograft of glioblastoma stem-like cells (left) almost inevitabely develop a tumor\u00a0<\/strong><\/p>

shARNT2: Silencing of ARNT2<\/strong>
ARNT2 knock-down (right) strikingly reduce tumor incidence in mice grafted with glioblastoma stem-like cells<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Longitudinal analysis of bioluminescence allows to reveal tumor incidence and the timing of its occurrence.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Arfaoui, A. et al.<\/em> A genome\u2010wide RNAi screen reveals essential therapeutic targets of breast cancer stem cells<\/strong>. EMBO Molecular Medicine<\/em> (2019)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Untreated (control)
<\/strong>Primary breast cancer xenografts engender liver and lung metastasis formation in untreated mice
Salinomycin treated
<\/strong>Salinomycin alone does not significantly impair metastasis development
JQ1 treated
<\/strong>JQ1 alone does not significantly impair metastasis development<\/p>

Salinomycin\/ JQ1 treated
<\/strong>The salinomycin\/JQ1 combination significantly reduces metastasis formation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Treatment efficacy on metastasis development is quantified in two primary human breast cancer xenograft models (CRCM434 and 404), generated from patients with chemo-na\u00efve triple-negative breast tumors.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Drug combination assay and ex vivo<\/em> imaging display the\u00a0synergistic interaction of salinomycin\/JQ1 association to limit breast cancer metastatic development.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Arfaoui, A. et al.<\/em> A genome\u2010wide RNAi screen reveals essential therapeutic targets of breast cancer stem cells<\/strong>. EMBO Molecular Medicine<\/em> (2019)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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CTRL: Untreated (control)
<\/strong>Primary breast cancer xenografts engender liver and lung metastasis formation in untreated mice
SAL: Salinomycin treated
<\/strong>Salinomycin alone does not significantly impair metastasis development
JQ1: JQ1 treated
<\/strong>JQ1 alone does not significantly impair metastasis development<\/p>\n

SAL+JQ1: Salinomycin\/ JQ1 treated
<\/strong>The salinomycin\/JQ1 combination is efficent for significant reduction of metastasis formation<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Treatment efficacy on metastasis development is quantified in two primary human breast cancer xenograft models (CRCM434 and 404), generated from patients with chemo-na\u00efve triple-negative breast tumors.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Drug combination assay and ex vivo<\/em> imaging display the\u00a0synergistic interaction of salinomycin\/JQ1 association to limit breast cancer metastatic development.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Neuroscience<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The central nervous system is a complex and fascinating structure that remains yet complicated to image. Biospace Lab supports neurobiologists in this challenge.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Image the brain in vivo
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\u00a0Detect optical signals from distinct brain regions through the intact skull.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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monitor neuronal activity
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\u00a0Visualize rapid Ca\u00b2\u207a-dependent signals to monitor neuronal activity in real time.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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study awake animals
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\u00a0Reduce anesthesia-related bias and explore behavioral responses in freely moving animals.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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follow disease progression<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Track neurological disease progression longitudinally in the same animal.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Guglielmetti, C. Prael, J. et al. Multimodal imaging of subventricular zone neural stem\/progenitor cells in the cuprizone mouse model reveals increased neurogenic potential for the olfactory bulb pathway, but no contribution to remyelination of the corpus callosum<\/b>. NeuroImage (2014)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Untreated (control)<\/b><\/span><\/p>

In situ labeled NPCs of the subventricular zone (SVZ) migrate towards the olfactory bulb (OB)<\/p>

\u00a0<\/strong><\/p>

Multiple sclerosis model<\/strong>
Significantly increased migration of NPCs from the SVZ to the OB is evidenced in cuprizone-treated mice<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Longitudinal in vivo<\/em> tracking allows
monitoring neural progenitor cells (NPCs)
within distinct brain regions.<\/p>

Increased proliferation and significant alteration of NPC migration from the SVZ to the OB has been highlighted in a murine model of multiple sclerosis, induced by cuprizone treatment.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Guglielmetti, C. Prael, J. et al. Multimodal imaging of subventricular zone neural stem\/progenitor cells in the cuprizone mouse model reveals increased neurogenic potential for the olfactory bulb pathway, but no contribution to remyelination of the corpus callosum<\/b>. NeuroImage (2014)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Untreated<\/strong> (control)
<\/b><\/span>In situ labeled NPCs of the subventricular zone (SVZ) migrate towards the olfactory bulb (OB)<\/span><\/p>

Cuprizone:\u00a0<\/span><\/strong>Multiple sclerosis model
<\/strong>Significantly increased migration of NPCs from the SVZ to the OB is evidenced in cuprizone-treated mice<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Longitudinal in vivo<\/em> tracking
\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 allows monitoring neural
\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 progenitor cells (NPCs)
\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 within distinct brain regions.<\/p>

Increased proliferation and significant alteration of NPC migration from the SVZ to the OB has been highlighted in a murine model of multiple sclerosis, induced by cuprizone treatement.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Gakuba, C. et al.<\/em> General anesthesia inhibits the activity of the \u201cglymphatic system\u201d<\/strong>. Theranostics<\/em> (2018)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\u00a0<\/p>

Awake
<\/strong>The indocyanine green fluorescent tracer injected into the cisterna magna (orange) diffuses through the brain and is readily detectable in the forebrain (red)


Anesthetized (isoflurane)
<\/b><\/span>The intracisternally injected indocyanine green remains near the injection site in the anesthetized mice<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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As soon as 30 min after intracisternal injection, the amount of indocyanine green in the forebrain of awake mice is significantly higher with respect to anesthetized mice.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Longitudinal in vivo <\/i>near-infrared imaging of freely moving mice revealed that cerebrospinal fluid flow circulation is mainly active during wakefulness
and significantly impaired during
general anesthesia.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Gakuba, C. et al.<\/em> General anesthesia inhibits the activity of the \u201cglymphatic system\u201d<\/strong>. Theranostics<\/em> (2018)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Awake
<\/strong>The indocyanine green fluorescent tracer injected into the cisterna magna (orange) diffuses through the brain and is readily detectable in the forebrain (red)<\/p>

Anesthetized (isoflurane)
<\/b>The intracisternally injected indocyanine green remains near the injection site in the anesthetized mice<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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As soon as 30 min after intracisternal injection, the amount of indocyanine green in the forebrain of awake mice is significantly higher with respect to anesthetized mice.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Longitudinal in vivo<\/em> near infrared imaging of freely moving mice revealed that cerebrospinal fluid flow circulation is mainly active during wakefulness and significantly impaired during general anesthesia.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Rogers, K. L. et al.<\/i> Non-Invasive In Vivo Imaging of Calcium Signaling in Mice<\/b>. PLoS ONE<\/i> (2007)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Seizure induced by kainate administration in non-anesthetized mice, provokes highly synchronized, bilateral Ca2+<\/sup> transients.<\/p>

This increased Ca2+<\/sup> activity is measured using GFP-aequorin
as a bioluminescent Ca2+<\/sup>-reporter.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Real-time bioluminescent signal acquisition makes it possible to detect
rapid Ca2+<\/sup> transients.<\/p>

A marked increase in Ca2+<\/sup> activity occurred approximately 15 minutes after drug administration.
This phenomenon is evidenced as oscillations in which Ca2+<\/sup> spikes only last a few seconds.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Stem Cell Biology<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Stem cells play an essential role in embryonic development, and tissue homeostasis and renewal. Biospace Lab provides versatile solutions that offer decisive advantages for investigating and exploiting the unique potential of stem cells.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Track stem cells in space and time
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\n\t\t\t\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Follow stem cell localization, migration and persistence longitudinally.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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MONITOR CELL FATE & DIFFERENTIATION<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Follow migration and maturation events leading to cell differentiation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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ASSESS CELL SURVIVAL<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Monitor key cellular processes including proliferation, survival and apoptosis.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Tennstaedt, A. et al.<\/i> Human neural stem cell intracerebral grafts show spontaneous early neuronal differentiation after several weeks<\/b>. Biomaterials<\/i> (2015)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Early neuronal reporter<\/strong>
Newly born neuron signal increases within the first month after NSC implantation<\/p>

\u00a0<\/p>

Constitutively expressed reporter (control)
<\/strong>The signal remains stable over time<\/p>

\u00a0<\/strong><\/p>

\u00a0<\/p>

\u00a0<\/p>

Mature neuronal reporter
<\/strong>Ongoing maturation of neurons and synaptogenesis is detectable from 3 months post-implantation<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Tennstaedt, A. et al.<\/i> Human neural stem cell intracerebral grafts show spontaneous early neuronal differentiation after several weeks<\/b>. Biomaterials<\/i> (2015)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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1st<\/sup> line: Early neuronal reporter<\/strong>
Newly born neuron signal increases within the first month after NSC implantation<\/p>

2nd<\/sup> line: Constitutively expressed reporter (control)
<\/strong>The signal remains stable over time<\/p>

3rd<\/sup> line: Mature neuronal reporter
<\/strong>Ongoing maturation of neurons and synaptogenesis is detectable from 3 months post-implantation<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"Taennstaed\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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VIROLOGY<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Systems can be installed and maintained in BSL-2 and BSL-3 environments..<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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TRACK PATHOGEN DISSEMINATION<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Visualize infection spread throughout the body over time and at very low levels.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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CAPTURE EARLY INFECTION EVENTS<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Detect rapid biological events from the very first seconds.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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EVALUATE THERAPEUTIC RESPONSE<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Assess treatment efficacy and biological response over time.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Pavlidis, I. et al. Cervical epithelial damage promotes Ureaplasma parvum ascending infection, intrauterine inflammation and preterm birth induction in mice. Nature Communications (2020)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"Pavlidis\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Controls<\/strong>
No signal is detectable in untreated (PBS) or in N-9 treated mice when not subjected to infection (USM)<\/p>

Untreated<\/strong>
Low bacterial load is observable in untreated mice infected with a luciferase-expressing Ureaplasma parvum<\/em> strain (UP)<\/p>

N-9 induced cervical<\/strong> damage<\/strong>
Intravaginal exposure to N-9 facilitates intrauterine UP infection\u00a0<\/p>

\u00a0<\/p>

Bioluminescent bacteria emanate
high-intensity signals with the expected
shape and location of the uterus, showing bulges representing gestating foetus<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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In vivo<\/em> imaging makes it possible to visualize the ascending
Ureaplasma parvum<\/em>\u00a0infection in pregnancy,
demonstrating the crucial role of the cervical epithelium
as a barrier against ascending infection and preterm birth.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Pavlidis, I. et al. Cervical epithelial damage promotes Ureaplasma parvum ascending infection, intrauterine inflammation and preterm birth induction in mice. Nature Communications (2020) <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Controls<\/strong>
No signal is detectable in untreated (PBS) or in N-9 treated mice when not subjected to infection (USM)<\/p>

Untreated<\/strong>
Low bacterial load is observable in untreated mice infected with a luciferase-expressing Ureaplasma parvum<\/em> strain (UP)<\/p>

N-9 induced cervical<\/strong> damage<\/strong>
Intravaginal exposure to N-9 facilitates intrauterine UP infection<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Bioluminescent bacteria emanate
high-intensity signals with the expected shape and location of the uterus, showing bulges representing gestating foetuses<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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In vivo<\/em> imaging allows to visualize the ascending Ureaplasma parvum<\/em>\u00a0infection in pregnancy, demonstrating the crucial role of the cervical epithelium as a barrier against ascending infection and preterm birth.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Raaben, M. et al. Non-invasive imaging of mouse hepatitis coronavirus infection reveals determinants of viral replication and spread in vivo. Cellular Microbiology (2009)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Mice with different genetic backgrounds have been intranasally inoculated with
luciferase-expressing mouse hepatitis virus (MHV)<\/p>

BALB\/c mouse strain<\/strong>
BALB\/c mice display the highest luminescent signal<\/p>

C57BL\/6 mouse strain<\/strong>
C57BL\/6 mice have an intermediate phenotype compared to the other genetic backgrounds<\/p>

129SvEv mouse strain<\/strong>
129SvEv mice are significantly less susceptible to MHV infection<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Non-invasive whole-body imaging of viral infection in living animals allows to monitor its spatial and temporal progression in real-time.<\/p>

Follow-up of viral replication can be performed in parallel for different animals, here unveiling the variable susceptibility of various inbred mouse strains to MHV infections.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Weinmann, J. et al.<\/em> Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants<\/strong>. Nature Communications<\/em> (2020)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Pharmacology \/ biodistribution<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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EXPLORE SMALL AREAS OF INTEREST<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Visualize small regions in the brain and other organs with excellent spatial resolution.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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MAP DRUG & PROTEIN DISTRIBUTION<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Visualize the anatomical distribution of proteins, drugs and other compounds within tissues.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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QUANTIFY RADIOLABELED COMPOUNDS<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Measure radiolabeled substances in tissue sections for binding and in situ<\/em> hybridization (ISH) experiments.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ASSESS DOSE-DEPENDENT EFFECTS<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Quantify dose effects in pharmacological studies, including radiolabeled ligand displacement experiments.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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SUPPORT PET & SPECT STUDIES<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Complement and validate preclinical PET or SPECT experiments with high-resolution ex vivo autoradiography.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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COMPARE MULTIPLE RADIOLABELED MARKERS<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Investigate metabolism, perfusion and interstitial fluid distribution through simultaneous imaging and quantification of different radiolabeled markers in histological slices.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Zinnhardt, B. et al.<\/em> Molecular imaging of immune cell dynamics during de- and remyelination in the cuprizone model of multiple sclerosis by [18<\/sup>F]DPA-714 PET and MRI<\/strong>. Theranostics<\/em> (2019)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Comparison of in vivo PET data with ex vivo autoradiography. (A) Ex vivo autoradiography confirms the in vivo spatial distribution of [18F]DPA-714 (n = 1-2).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Kryza, D. et al.<\/em> Ex vivo and in vivo imaging and biodistribution of aptamers targeting the human Matrix MetalloProtease-9 in melanomas<\/strong>. PLoS ONE<\/em> (2016)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Comparison of the results obtained by radiolabeling of representative tumor tissue sections with 111In-DOTA-F3B aptamer (left image) and 111In-DOTA-control sequence (right image).The difference of activity seems to increase in a tumor grade-dependent manner. (A) Lentigo malignant melanoma, (B) Nodular melanoma, (C) Mostly metastatic node.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Alitalo, O., Rantam\u00e4ki, T. & Huhtala, T. Digital autoradiography for efficient functional imaging without anesthesia in experimental animals: Reversing phencyclidine-induced functional alterations using clozapine<\/strong>. Progress in Neuro-Psychopharmacology and Biological Psychiatry<\/em> (2020)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\u201cWith the advances in direct particle-counting systems, the new digital ARG devices have surpassed the conventional film and phosphor screen-based ARG in linearity, dynamic range, and sensitivity, reducing the acquisition times from months to just few hours.\u201d<\/em><\/p>

\u00a0<\/p>

\u201c<\/em>An example of qualitative results acquired from control group with BetaImager TRacer using 3H-labeled 2-deoxy-d-glucose as a tracer. The acquisition was performed for 6 h on a full-field zoom setting (250 \u00d7 200 mm)”<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Alitalo, O., Rantam\u00e4ki, T. & Huhtala, T. Digital autoradiography for efficient functional imaging without anesthesia in experimental animals: Reversing phencyclidine-induced functional alterations using clozapine<\/strong>. Progress in Neuro-Psychopharmacology and Biological Psychiatry<\/em> (2020)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\u201cWith the advances in direct particle-counting systems, the new digital ARG devices have surpassed the conventional film and phosphor screen-based ARG in linearity, dynamic range, and sensitivity, reducing the acquisition times from months to just few hours.\u201d<\/em><\/p>

\u00a0<\/p>

\u201c<\/em>An example of qualitative results acquired from control group with BetaImager TRacer using 3H-labeled 2-deoxy-d-glucose as a tracer. The acquisition was performed for 6 h on a full-field zoom setting (250 \u00d7 200 mm)”<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Virtually any beta-emitting radioisotope with sufficient energy will generate Cerenkov luminescence in vivo, including those for which no current in vivo imaging solutions exist; such as 32P, 90Y and 90Sr.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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2.5 \u03bcCi of 90Y radiotracer concentrated in the pancreas of a mouse imaged with PhotonIMAGER\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/p>

\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Cerenkov luminescence with the 4View module of the PhotonIMAGER.<\/p>

Images of a mouse from 4 different angles 4 h after the injection of 50 \u03bcCi 32P. Cerenkov luminescence signal appears in subcutaneous tumor \u2014 with a long-pass (530 nm) filter.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

PRECLINICAL IMAGING APPLICATIONS Explore biology across a wide range of preclinical applications From oncology and neuroscience to virology, stem cell research and biodistribution, explore how Biospace Lab imaging technologies help researchers visualize, quantify and follow biological processes in vivo and ex vivo. ONCOLOGY Tumor growth \u00b7 Metastasis \u00b7 Therapy response NEUROSCIENCE Brain imaging \u00b7 Neural […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_thinkrank_schema_form_data":"","_thinkrank_selected_schema_type":"","_thinkrank_additional_schemas":"","_thinkrank_canonical_url":"","_thinkrank_og_title":"","_thinkrank_og_description":"","_thinkrank_og_image":"","_thinkrank_twitter_title":"","_thinkrank_twitter_description":"","_thinkrank_twitter_image":"","_thinkrank_imported_from":"","_thinkrank_focus_keywords":["preclinical optical imaging applications bioluminescence fluorescence"],"_thinkrank_focus_keyword":"preclinical optical imaging applications bioluminescence 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